Product Overview

SS-31 (chemically classified as a mitochondria-targeted antioxidant peptide and structurally known as Elamipretide or Bendavia) provides a highly advanced, ultra-purified reference standard for assessing complex cellular bioenergetics and organelle protection signaling profiles. In multi-variable metabolic pathway research and neurodegenerative cell line assays, tracking how protective small molecules stabilize inner mitochondrial structures requires absolute chemical purity. By utilizing a unique tetrapeptide sequence (D-Arg-Dmt-Lys-Phe-NH2), this compound bypasses standard receptor-mediated transport to directly penetrate cell membranes and enrich the mitochondrial matrix, delivering immediate structural support where cellular energy is generated.

At Titan Labs, we supply this crucial reference standard in a highly stable, lyophilized crystalline powder configuration containing exactly 50mg of active peptide per vial. Every single batch is strictly verified at an over 99% pure active pharmaceutical ingredient (API) configuration via High-Performance Liquid Chromatography (HPLC) testing. This uniform 50mg solid format provides advanced research laboratories with the consistent molecular volume necessary to execute precise reconstitution titrations, deep cell line exposure reviews, and multi-phase oxidative stress mappings free from cross-batch inconsistencies.

What is SS-31 Peptide 50mg?

SS-31 50mg is a unique, water-soluble small molecule that exhibits a highly specialized pharmacological profile marked by its structural affinity for specific mitochondrial lipids. Structurally, its signature innovation involves alternating basic and aromatic amino acid residues combined with a dimethyltyrosine (Dmt) modification. This distinct geometric layout allows the peptide to carry a net positive charge at physiological pH, drawing it directly toward the negatively charged inner mitochondrial membrane without relying on mitochondrial membrane potential metrics for entry.

Additionally, this structural configuration prevents the rapid degradation typically seen with non-modified synthetic peptides. Instead of breaking down prematurely, research demonstrates that this compound concentrates hundreds of times higher within the inner membrane grid compared to the cytoplasm. Furnished in a precise 50mg research vial, this compound gives investigators the exact tolerances needed to maintain strict chemical controls across multiple parallel cellular stress assay groups.

Mechanisms of Mitochondrial Protection and ATP Support

In cellular translation, molecular genetics, and target-specific organelle degradation models, SS-31 operates as a premier agent for investigating structural cellular resilience pathways. The underlying molecular interactions proceed through several specific phases:

Cardiolipin Membrane Target Binding

SS-31 penetrates the outer organelle layer to attach directly to cardiolipin, an essential structural phospholipid expressed exclusively on the inner mitochondrial membrane.

Electron Transport Chain Stabilization

The peptide-cardiolipin association normalizes the structural curve of the inner membrane cristae, preventing the disruption of electron transport chain supercomplexes during stress events.

Reduction of Pathogenic Oxidative Stress

By maintaining optimal electron transport geometry, the compound drastically minimizes the leakage of electrons, inhibiting the overproduction of harmful reactive oxygen species (ROS).

Interruption of Permeability Pore Activation

The stabilized membrane architecture blocks the premature opening of the mitochondrial permeability transition pore, shielding the cell from early cytochrome c release and subsequent apoptotic breakdown.

Optimization of Adenosine Triphosphate Synthesis

With the electron transport chain running smoothly, the cell preserves its membrane potential baseline, driving steady, efficient Adenosine Triphosphate (ATP) synthesis under conditions of severe energy depletion.

SS-31 Peptide 50mg Benefits

• Isolated Bioenergetic Mapping: Direct target interaction ensures clean data collection regarding mitochondrial respiration free from secondary nuclear receptor variables.

• Membrane Potential Independence: Penetrates damaged or energy-depleted mitochondria successfully, allowing for the accurate tracking of severe injury recovery phases.

• Superior Antioxidant Precision: Scavenges localized reactive oxygen species right at the source of production rather than non-selectively clearing cytoplasmic molecules.

• Advanced Neuroprotective Analysis: Demonstrates superior performance in evaluating neuronal cell line survival against ischemia, trauma, or amyloid toxicity protocols.

• Exceptional Structural Uniformity: Configured as a highly stable lyophilized solid to guarantee long-term shelf life and error-free micro-molar calculations.

SS-31 Peptide 50mg Side Effects

• Micro-Environment Concentration Fluctuations: High dosing saturation can alter local membrane fluidity metrics due to the strong structural binding with cardiolipin layers.

• Cellular Transport Variations: Excessive exposure levels may modify standard organic cation transporter paths in specific renal cell models.

• Reconstitution Stability Shifts: Once dissolved in aqueous solutions, baseline peptide degradation speeds increase if the matrix is exposed to fluctuating temperatures.

• Injection Site Metrics in Vivo: In living animal models, localized tissue interactions can provoke transient inflammatory responses or minor cellular changes at the injection zone.

Key Features

• Premium, analytical-grade SS-31 peptide (99%+ HPLC verified API)

• Stable 50mg lyophilized format tailored for prolonged storage and highly accurate dilution protocols

• Total selectivity for cardiolipin targets, ensuring pure, unclouded inner membrane analysis

• Rapid, transporter-independent cellular entry dynamics to maximize exposure consistency

• Manufactured under sterile, ultra-purified laboratory quality protocols

Primary Uses in Research

• Mapping the specific electron transfer rates and structural variations within the inner mitochondrial cristae

• Studying the exact protective mechanics of cardiolipin binding during induced lipid peroxidation assays

• Creating predictive cellular models for reversing severe mitochondrial myopathies, tissue ischemia, and acute organ trauma lines

• Investigating the structural interactions and competitive inhibition dynamics against local apoptotic signaling channels

• Analyzing cellular transport resistance and metabolic survival metrics under induced oxidative or glucotoxic stress states

How to Use SS-31 Peptide 50mg

To prepare this reference standard for experimental assays, calculate the exact concentration required for your specific liquid media or cell culture parameters. SS-31 50mg is supplied as a lyophilized powder, requiring proper reconstitution before immediate titration.

Gently inject a compatible sterile buffer, such as Phosphate-Buffered Saline (PBS) or sterile water, directly into the vial. Allow the solution to dissolve completely without vigorous shaking to protect the delicate peptide structure. Maintain absolute sterile conditions throughout the sampling and testing process to avoid contamination of the reference medium.

Product Specifications

• Device Type: Lyophilized Powder / Analytical Reference Standard

• Active Compound: SS-31 (Elamipretide Acetate)

• Quantity: 50mg per Vial

• CAS Number: 1334953-95-5

• Chemical Formula: C32H49N9O5

• Molecular Weight: 639.80 g/mol

• Intended Use: Scientific Laboratory Research and Development

• Brand: Titan Labs

• Purity Standard: Exceeds 99% via High-Performance Liquid Chromatography (HPLC)

Storage Guidelines

Store SS-31 50mg vials in a dark, moisture-free freezer at a controlled temperature of minus 20 degrees Celsius for long-term preservation (up to 24 months). Keep the protective vial cap completely intact until the exact moment of testing to shield the dry standard from humidity, direct ultraviolet radiation, and atmospheric contamination. Once reconstituted into a liquid standard, use the solution immediately or aliquot and store at minus 80 degrees Celsius to avoid repeated freeze-thaw cycles that break down the peptide chain.

Related Category

Premium synthetic mitochondrial-targeted peptide standard for inner membrane stabilization, cardiolipin protection analysis, oxidative stress mitigation research, and cellular energy kinetic studies. Browse our Peptides and Small Molecules category.

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• Cellular Antioxidant Kit – Advanced Organelle Oxidative Stress Assay Set

Frequently Asked Questions

Why is SS-31 supplied as a lyophilized powder rather than a pre-dissolved liquid format?

Peptide chains are highly sensitive to hydrolytic cleavage when stored in liquid states over long periods. Providing this reference standard as a stable 50mg lyophilized solid ensures complete chemical preservation, prevents early degradation, and allows research laboratories to mix fresh, custom concentrations optimized for their specific testing windows.

What is the exact structural target of SS-31 inside the cell?

Unlike general antioxidants that spread randomly through the cytoplasm, SS-31 targets cardiolipin specifically. Cardiolipin is a unique phospholipid found exclusively within the inner mitochondrial membrane, where it acts as a critical anchor for the respiratory chain proteins responsible for ATP production.

Does this compound require specific transport proteins to pass through cell walls?

No. The unique structural layout of basic and aromatic amino acids allows SS-31 to readily cross cell membranes via simple passive diffusion. It does not depend on specific transporter systems or normal cell membrane potential levels, meaning it can enter and study severely damaged cells effectively.

Does this peptide cause significant changes in the nuclear genetic transcription of healthy cells?

SS-31 acts primarily through direct physical stabilization of the mitochondrial inner membrane architecture rather than interacting with nuclear hormone receptors. While it alters downstream genetic pathways by preserving overall cell health and suppressing stress-induced apoptosis genes, it does not act as a direct nuclear transcription initiator.

Conclusion

SS-31 50mg vials from Titan Labs deliver the exceptional chemical clarity, structural stability, and target-specific organelle protection required for meticulous cellular energy and oxidative stress research. Incorporating our premium, HPLC-validated formulation into your protocol ensures the collection of highly reproducible data and sharp analytical baselines. Combine this elite mitochondrial standard with our tissue repair peptides or specialized cellular assays to explore comprehensive metabolic recovery and advanced cell survival modeling. Browse our full Peptides and Small Molecules catalog, or select from the related listings above to complete your research setup today!